Ph.D. Medicine 03/04 to08/08 Chonbuk National University, South Korea
M.Sc. Biochemistry 03/02 to 03/04 University of Kashmir, India
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Positions and Employment
2005 Mar~2008 Aug: Graduate Research/Teaching Asst., Dept. of Biochemistry, School of
Medicine, Chonbuk National University, South Korea
2008 Sep~2010 May: Postdoctoral Fellow, Dept. of Biochemistry, School of Medicine,
Chonbuk National University, South Korea
2010 June~2012 Sep: Postdoctoral Fellow, Dept of Internal Medicine, School of
Medicine, University of Missouri, Columbia-MO, USA
2012 Sep~2018 Sep: Assistant Professor, College of Medicine, King Saud University,
Riyadh, Saudi Arabia.
2018 Sep~Present: Associate Professor, College of Medicine, King Saud University,
Riyadh, Saudi Arabia.
2
Research Support
Highly recommended and funded research projects
Agency: KACST, KSA
Project No.: 12-MED2476-02
P.I.: Rukhsana Gul
Highly recommended research projects
Agency: KACST, KSA
Project No.: 12-MED2476-02
P.I.: Rukhsana Gul
Recommended Research Projects
Agency: KACST, KSA
Project No.: 14-BIO688-02-R
Co-I.: Rukhsana Gul
Honors and Awards
Invited for Gordon research conference and Seminar on Angiotensin, Emerging and
Evolving Paradigms in the Renin Angiotensin System, USA 2012.
Young Investigator award from Veterans affairs, University of Missouri, USA 2011.
Chonbuk National University Post doctorial fellowship for International fellows, S. Korea
2008– 2010.
Best dissertation award form Medical School, Chonbuk National University, S. Korea 2008
Young scientist award from Medical School, Chonbuk National University, S. Korea 2007
Korean Research Foundation (KRF) scholarship for international students, S. Korea 2006 - 08
Award for the best presentation from Korean Society of Medical Biochemistry and
Molecular Biology, S. Korea 2007
Other Experience and Professional Membership
2011-present Member of American Heart Association
2010-present Member of American Physiological Society
3
Publications
1. Alfadda AA, Sallam RM, Gul R, Hwang I, Ka S. Endophilin A2: A Potential Link to
Adiposity and Beyond. Mol Cells. 2017 Nov 30;40(11):855-863. doi:
10.14348/molcells.2017.0137
2. M. A. Dar, R. Gul, A. A. Alfadda, M. R. Karim, D. W. Kim, C. L. Cheung, N. H.
Alharthi, L. Pulakat. Size-dependent Effect of Nanoceria on their Antibacterial
Activity towards Escherichia coli. Science of Advanced Materials, Vol. 9, pp. 1-6,
2017.
3. Gul R, Park DR, Shawl AI, Im SY, Nam TS, Lee SH, Ko JK, Jang KY, Kim D, Kim
UH. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-
Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-
Adrenergic Stimulation. PLoS One. 2016 Mar 9;11(3): e0149125. DOI:
10.1371/journal.pone.0149125.
4. Gul R, Mahmood A, Luck C1, and Pulakat L. Regulation of cardiac miR-208a, an
inducer of obesity, by Rapamycin and Nebivolol. 2015, Obesity. Nov. 2015; (23):
2251–2259.
5. Nanjundan Ashok Kumar, M. A. Dar, Rukhsana Gul and Jong-Beom Baek, “Graphene
and molybdenum disulfide hybrids: synthesis and applications”, 2015; Materials
Today, 18(2) 286–298.
6. Arnold N, Koppula PR, Gul R, Pulakat L. Regulation of cardiac expression of the
diabetic marker microRNA miR-29. July 2014; PLoS One, (9): e103284 .
7. Erickson CE*, Gul R*, Pulakat L, and Andresen T. The β-blocker Nebivolol is a
GRK/β-arrestin Biased Agonist., August 2013: PLoS One, (8): e71980 .
8. Raad M, Tal T, Gul R, Mondello S, Zhang Z, Boustany RM, Kobaissy F.
Neuroproteomics Approach & Neurosystems Biology Analysis: ROCK Inhibitors as
Promising Therapeutic Targets in Neurodegeneration & Neurotrauma.
Electrophoresis. 2012 Dec; 33(24):3659-68.
9. Gul R, Ramdas M, Mandavia CH, Sowers JR, Pulakat L. RAS-mediated adaptive
mechanisms in cardiovascular tissues: Confounding factors of RAS blockade therapy
and alternative approaches. Cardiorenal Med. 2012 Dec;2(4):268-280 .
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10. Gul R, Demarco VG, Sowers JR, Whaley-Connell A, Pulakat L. Regulation of
Overnutrition-Induced Cardiac Inflammatory Mechanisms. Cardiorenal Med. 2012
Aug; 2(3):225-233 .
11. Ma L*, Gul R*, Habibi J*, Yang M, Pulakat, Whaley-Connell A, Ferrario C, and
Sowers JR. Nebivolol Improves Diastolic Dysfunction and Myocardial Remodeling
through Reductions in Oxidative Stress in the Transgenic (mRen2) Rat. Am J Physiol
Heart Circ Physiol. 2012 Jun 1; 302(11):H2341-51.
12. Pulakat L, Aroor AR, Gul R, and Sowers JR. Cardiac Insulin Resistance and
microRNA Modulators. Exp Diabetes Res.2012; 2012:654904 .
13. Gul R, Shawl AI, Kim SH, Kim UH. Co-operative interaction between reactive oxygen
species and Ca2+ signals contributes to angiotensin II-induced hypertrophy in adult rat
cardiomyocytes. Am J Physiol Heart Circ Physiol 2012 Feb 15; 302(4):H901-9 .
14. Pulakat L, DeMarco V, Ardhanari S, Chockalingam A, Gul R, and Sowers JR.
Adaptive Mechanisms to Compensate for overnutrition-induced Cardiovascular
Abnormalities. Am J Physiol Regul Integr Comp Physiol. 2011 2011 Oct; 301(4):
R885-95 .
15. DeMarco V, Johnson M, Habibi J, Pulakat L, Gul R, Hayden M, Tilmon R, Dellsperger
K, Winer N, Whaley-Connell A, and Sowers JR. Comparative Analysis of Telmisartan
and Olmesartan on Cardiac Function in the TG(mRen2)27 Rat. Am J Physiol Heart
Circ Physiol 2011; 300:H181-90 .
16. Shah A, Gul R, Yuan K, Shan G, Oh YB, Kim UH, and Kim SH. Angiotensin-(1-7)
stimulates high atrial pacing-induced ANP secretion via Mas/PI3 kinase/Akt axis and
Na+/H+ exchanger. Am J Physiol Heart Circ Physiol 2010; 298:H1365-74 .
17. Kim SY, Park KH, Gul R, Jang KY, and Kim UH. Role of Kidney ADPR-cyclase in
Diabetic Nephropathy. Am J Physiol Renal Physiol. 2009; 296:291-7 .
18. Gul R, Park JH, Kim SY, Jang KY, Chae JK, Ko JK, Kim UH. Inhibition of ADP-
ribosyl cyclase attenuates angiotensin II-induced cardiac hypertrophy. Cardiovasc Res.
2009; 81:582-91.
19. Park KH, Kim SY, Gul R, Kim BJ, Jang KY, Chung HT, Sohn DH. Fatty acids
ameliorate doxorubicin-induced intracellular Ca2+ increase and apoptosis in rat
cardiomyocytes. Biol Pharm Bull. 2008; 31:809-15.
5
20. Kim SY, Gul R, Rah SY, Kim SH, Park SK, Im MJ, Kwon HJ, and Kim UH.
Molecular Mechanism of ADP-Ribosyl Cyclase Activation in Angiotensin II Signaling
in Murine Mesangial Cells. Am J Physiol Renal Physiol. 2008;294: F982-F989.
21. Gul R, Kim SY, Park KH, Kim BJ, Kim SJ, Im MJ, and Kim UH. A Novel Signaling
Pathway of ADP-ribosyl Cyclase Activation by Angiotensin II in Adult Rat
Cardiomyocytes. Am J Physiol Heart Circ Physiol. 2008; 295:H77-88.
Published abstracts
1. Shah A, Gul R, Yuan K, Shan G, Oh YB, Kim UH, and Kim SH. Angiotensin-(1-
7) stimulates high atrial pacing-induced ANP secretionFASEB J April 6, 2010
24:1040.2
2. Gul R, DeMarco V, Arnold S, Whaley-Connell A, Sowers JR, and Pulakat L.
Pleiotrophic effects of β-adrenergic receptor blocker nebivolol on Angiotensin II
type 1-receptor mediated signaling in myocardium. HBPR 2011.
3. Gul R, Arnold S, DeMarco V, Ma L, Whaley-Connell A, Hayden MR, Sowers JR,
and Pulakat L. Nebivolol-mediated inhibition of nutrient sensor mTOR- and
inflammatory marker JAK2-mediated signaling in myocardium: Involvement of
Angiotensin II receptors. FASEB J March 17, 2011 25:1032.10
4. Gul R, Erickson CE, Sowers JR, Pulakat L, and Andresen BT. Is nebivolol, which
is classified as a β1-adrenegic receptor antagonist, a biased agonist? FASEB J
March 17, 2011 25:626.5
5. Pulakat L, Gul R, Arnold S, DeMarco V, and Sowers JR. Modulation of
microRNA miR-29c in a novel cross-talk between mTOR complex 1 and
Angiotensin II type 2 receptor AT2R: an adaptive mechanism in over-nutrition.
FASEB J March 29, 2012 26:615.9.
6. Gul R, DeMarco V, Rajyaguru N, Speth RC and Pulakat L. Regulation of Cardiac
MicroRNA miR-208a by Angiotensin II and the Beta-Adrenergic Receptor
Blocker Nebivolol. Hypertension, 2012; 60: A652
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7. Arnold N, Someshekhara D, Koppula P, Gul R, Speth R and Pulakat L.
Rapamycin attenuates expression of anti-inflammatory AT2R and anti-apoptotic
MCL-1. FASEB J April 9, 2013 27:835.13.
8. Mahmood A, Gul R, Luck C and Pulakat L. Role of Cardiac mir-208a in
Nebivolol-Mediated Signaling. FASEB J April, 2015 716.15
Conferences/Seminars attended
1. Gul R, Kim SY, Park KH, Rah SY, and Kim UH. Inhibition of ADP-ribosyl cyclase
attenuates angiotensin II-induced cardiac hypertrophy. Korean Society of Medical
Biochemistry and Molecular Biology, international symposium on Traslational Research, 2007
October, 24 ~ 25, Seoul, Korea.
2. Kim SY, Gul R, Park KH, Rah SY, Jang KY, and Kim UH. Angiotensin II-mediated
Kidney ADP-ribosyl cyclase activation can stimulate murine mesangial cells growth and
glomerular hypertrophy in diabetic mice kidney. Korean Society of Medical Biochemistry and
Molecular Biology, international symposium on Traslational Research, 2007 October, 24 ~ 25,
Seoul, Seoul, Korea.
3. Gul R, Kim SY, Kim BJ, Im MJ, and Kim UH. Molecular mechanism of ADPR-cyclase
activation by angiotensin II in cardiomyocytes. Korean Society of Medical Biochemistry and
Molecular Biology international symposium on Current Topics in Biomedical Sciences, 2006
October, 26~27, Seoul, Korea.
4. Kim SY, Gul R, Rah SY, Im MJ, and Kim UH. A small molecule inhibitor of kidney
ADPR-cyclase attenuates angiotensin II mediated Ca2+ signal in murine mesangial cells.
Korean Society of Medical Biochemistry and Molecular Biology international symposium on
Current Topics in Biomedical Sciences, 2006 October 26~27, Korea.
5. Gul R and Kim UH. Angiotension II-Induced Cardiac Hypertrophy Occurs via a
Crosstalk between Ca2+ and Oxidant Signal. Annual International Conference of KSMBMB
7
Korean Society of Medical Biochemistry and Molecular Biology, 2009 October 29-30, Seoul,
Korea.
6. Gul R, DeMarco V, Arnold S, Whaley-Connell A, Sowers JR, and Pulakat L. Nebivolol, a
beta- adrenergic receptor antagonist blocks Angiotensin II-mediated signaling in Heart.
HEALTH SCIENCES RESEARCH DAY Thursday, November 11, 2010, Columbia-MO, USA
7. Gul R, Arnold S, DeMarco V, Ma L, Whaley-Connell A, Hayden MR, Sowers JR, and
Pulakat L. Nebivolol mediated inhibition of nutrient sensor mTOR-and inflammatory marker
Jak2-mediated signaling in myocardium: Involvement of angiotensin receptors. Experimental
Biology meeting, Poster# 1032.10, April 9-13. Walter E. Washington Convention Center,
Washington, DC, USA.
8. Gul R, Erickson CE, Sowers JR, Pulakat L, and Andresen BT. Is nebivolol, which is
classified as a β1-adrenergic receptor antagonist, a biased agonist? Experimental Biology
meeting, Poster# 626.5, April 9-13. Walter E. Washington Convention Center, Washington,
DC, USA.
9. Gul R, DeMarco V, Ma L, Arnold S, Whaley-Connell A, Hayden MR, Sowers JR, and
Pulakat L. Reviving a beat up heart in metabolic syndrome: Multifaceted mechanisms of
Nebivolol to regulate Angiotensin II signaling. Harry S. Truman Memorial Veterans’ Hospital
Research Day May 4, 2011, Truman VA Auditorium, Columbia-MO, USA.
10. Gul R, DeMarco V, Arnold S, Whaley-Connell A, Sowers JR, and Pulakat L. Pleiotrophic
effects of β-adrenergic receptor blocker nebivolol on Angiotensin II type 1-receptor mediated
signaling in myocardium. High blood pressure research Council, Poster # 104, September 20-
24, 2011 Walt Disney World Dolphin Resort I Orlando, Florida., USA.
11. Gul R, DeMarco V, Sowers JR, Speth RC, and Pulakat L. Novel cross talk between AT1
receptor and β-adrenergic receptors: Roles of Jak/STAT, mTOR complex 1 and microRNA
miR-208a. Gordon research Conference and Seminar on Angiotensin, Emerging and Evolving
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Paradigms in the Renin Angiotensin System, February 26 - March 2, 2012, Four Points
Sheraton / Holiday Inn Express, Ventura, CA.
12. Gul R, DeMarco V, Rajyaguru N, Sowers JR, Speth RC, and Pulakat L. Regulation of
Cardiac MicroRNA miR-208a by Angiotensin II and the Beta-Adrenergic Receptor
Blocker Nebivolol.
13. Arnold N, Someshekhara D, Koppula P, Gul R, Speth R and Pulakat L. Rapamycin
attenuates expression of anti-inflammatory AT2R and anti-apoptotic MCL-1. Experimental
Biology meeting 2013, Poster# 17, April 20-24. BOSTON, USA.
14. Shawl AI, Gul R, and Kim UH. Role of CD38 in isoproterenol-induced Ca2+ Signaling in
cardiomyocytes. Korean Society of Medical Biochemistry and Molecular Biology,
international Conference on Integrating the basic human disease and its application, 2014,
May, 15 ~ 16, Seoul, Korea.
15. Mahmood A, Gul R, Luck C and Pulakat L. Role of Cardiac mir-208a in Nebivolol-
Mediated Signaling. Experimental Biology meeting 2015, Poster# .., Mar 28-Apr 02.
BOSTON, USA.
16. Gul R, Park DY, Im SY, Nam TS, and Kim UH. Nicotinic Acid Adenine Dinucleotide
Phosphate (NAADP) and Cyclic ADP-ribose (cADPR) Mediate Ca2+ Signaling in Cardiac
Hypertrophy Induced by β-Adrenergic Stimulation. Korean Society of Medical Biochemistry
and Molecular Biology, international Conference 2015, May, 13 ~ 14, Seoul, Korea.